Using HepG2 Cells to Model Liver Metabolism

HepG2 cells are a cornerstone model for studying hepatic metabolism, including Phase I and II enzyme activity. Their ability to express liver-specific enzymes provides insights into drug biotransformation and detoxification. Vero cells, lacking hepatic features, are not suitable for such studies. This distinction underscores HepG2's relevance in pharmacokinetics and toxicology testing.